The Observatory has conducted rigorous scientific analyses and produced groundbreaking reports that have increased scientific knowledge of climate change, pollution, and biodiversity loss and catalyzed change.

Plastics and Human Health

  • On August 3, 3025, we will publish a major paper in The Lancet announcing the launch if the Lancet Countdown on Health and Plastics. This is a joint project of Boston College and Heidelberg University.
    • Launch of this Countdown will coincide with the expected finalization of the UN Global Plastics Treaty. It will be an independent, indicator-based, health-focused global monitoring system: that identifies, tracks, and regularly report on a suite of geographically and temporally representative indicators that monitor progress toward reducing plastic exposures and mitigating plastics’ harms to human and planetary health.
  • In January 2025, we published a major paper titled, “The benefits of removing toxic chemicals from plastics”, in theProceedings of the National Academy of Sciences, Vol. 121 No. 0,e2412714121.
    • In this paper, we provide evidence of the health benefits of reducing chemical exposures in plastics. For the year 2015, we estimate that eliminating exposures to BPA and DEHP in countries constituting one-third of the world’s population would have saved approximately 600,000 lives. Reducing PBDEs to threshold levels in 2015 for women giving birth in countries accounting for 20% of global births would have saved approximately 11.7 million Intelligence Quotient (IQ) points.

  • In March 2023, we released a comprehensive analysis of Plastics and Human Health inAnnals of Global Health:doi.org/10.5334/aogh.4056. We found that plastics are closely linked to climate change because 99% of all plastics are made from fossil carbon, and because plastic production generates more greenhouse gases each year than Brazil. The study’s main findings were thatpollution causes harms to human health at every stage of the plastic life cycle – in production, use and disposal, and that these harms fall disproportionately upon the poor.
    • We have presented our findings in-person in Geneva, Switzerland to the World Health Organization and the UN Environment Programme.
    • Our recommendations are shaping the Global Treaty on Plastics, which is currently in fast-track development under the auspices of the UN Environment Programme.

Children’s Health and the Environment

  • January 2025: Published a major paper titled “Manufactured Chemicals and Children’s Health: The Need for New Law” in The New England Journal of Medicine. DOI:

  • October 2024: Published a systematic review on air pollution and cognitive impairment in children.
    • Alter NC, Whitman EM, Bellinger DC, Landrigan PJ. Quantifying the association between PM2.5 air pollution and IQ loss in children: A systematic review and meta-analysis. Environmental Health 2024; 23:101.
  • June 2024: Published the Second Edition of the Landrigan-Etzel Textbook of Children’s Environmental Health with Oxford University Press. This is the major textbook in the field.
    ISBN: 9780197662533

  • February 2024: In partnership with the Chinese Academy of Sciences, published a review article titled “Environmental Exposure and Child Health in China” in Environment International. DOI:

Air Pollution and Health

  • In July 2022, we completed a study of the burden of disease and death caused each year by climate change and air pollution in the cities and town of Massachusetts. This work was supported by the Barr Foundation of Boston and published in the journal, Environmental Health: doi: 10.1186/s12940-022-00879-3. We found, despite great improvements in air quality over the past 50 years, that current levels of climate-related air pollution are responsible for nearly 3,000 premature, preventable deaths each year in Massachusetts and that these deaths occur in every city and town at every income level across the state. We found additionally that air pollution is responsible each year for the loss of 2 million IQ points in Massachusetts children. We argued that a rapid statewide transition to clean, renewable energy is the most effective strategy for slowing climate change and preventing air pollution in Massachusetts.
    • To further disseminate the study’s findings and make them available to policy makers and the public, we have built a publicly accessible website:
  • In March 2022, we published a progress update on the Lancet Commission on Pollution and Health in Lancet Planetary Health: doi.org/10.1016/S2542-5196 (22)00090-0.
    • This analysis confirms the Lancet Commission’s 2018 findings:
      • Pollution in all its forms is closely related to climate change.
      • Pollution continues to be responsible for an estimated 9 million premature deaths globally per year and for massive economic losses.
    • The report argues the need for redoubled global efforts in the transition to clean energy and pollution prevention.
  • In 2020 and 2021, with support from the UN Environment Programme, we undertook analyses of the health and economic impacts of air pollution in India and Africa. Both of these reports that were published in Lancet Planetary Health: doi.org/10.1016/S2542-5196 (20)30298-9 and doi: 10.1016/S2542-5196(21)00201-1. Both argued that a rapid transition to clean, renewable energy is the most effective strategy for slowing climate change, preventing air pollution, and securing these countries’ futures.
    • These studies are now shaping health and economic policy in India and Africa

Pollution and Cardiovascular Disease

  • June 2024: Published an international review article in Nature Reviews Cardiology titled “Soil and Water Pollution and Cardiovascular Disease.”
    DOI:

  • March 2024: Published a report titled “The Burden of Cardiovascular Disease from Air Pollution in Rwanda” in Annals of Global Health. Main Finding: Ambient air pollution is an emerging but preventable cause of cardiovascular morbidity and mortality in sub-Saharan Africa. DOI:

Human Health and Ocean Pollution

  • In April 2024, with support from the World Resources Institute, the Observatory undertook a major analysis of the impacts of ocean health on human health. We found that a healthy ocean is essential for human health, but that the ocean is under threat from climate change, pollution, sea surface warming and ocean acidification. If humanity is to continue to benefit from the ocean, we must address global threats to the ocean such as climate change, pollution, and biodiversity loss through equitable partnerships, rigorous enforcement of laws and treaties, robust monitoring, and metrics that evaluate both the ocean’s natural capital and human well- being. This endeavor must explicitly prioritize human rights, equity, sustainability, and social justice. Reports that emerged from this research are the following:
    • Fleming LE, Landrigan PJ, Ashford OS, Whitman EM, et al. Enhancing Human Health and Wellbeing Through Sustainably and Equitably Unlocking a Healthy Ocean’s Potential. Annals of Global Health. July 2024. https://doi.org/10.5334/aogh.4471
    • Fleming LE Landrigan PJ, Ashford OS, Whitman EM, et al. How can a Healthy Ocean Improve Human Health & Enhance Wellbeing on a Rapidly Changing Planet? April, 2024.
  • In 2019 and 2020, we conducted a study of Human Health and Ocean Pollution in partnership with the Centre Scientifique de Monaco and the Woods Hole Oceanographic Institution and supported by the Prince Albert II of Monaco Foundation. This report was published in Annals of Global Health:
    • We cited the Boston Harbor clean-up as a highly successful and cost-effective case study of ocean pollution control.
    • Extensive media interviews and publicity followed release of this report.
    • The report has raised global consciousness of the impacts of ocean pollution and underscored the reality that ocean pollution can be prevented

We have published a series of shorter reports in high-impact journals addressing topical issues.

Plastics and Human Health

  • Landrigan PJ, Symeonides C, Raps H, Dunlop S. The Global Plastics Treaty. Why Is It needed?Lancet, 2023 Oct 17: S0140-6736(23)02198-0. doi: 10.1016/S0140-6736(23)02198-0
    • This report in The Lancet, the world’s most widely read medical journal, was published in October 2023, a few days before the third round of international negotiations on the UN Global Plastics Treaty. It builds on our March 2023 analysis of Plastics and Human Health and argues the need for a strong and legally binding treaty that ends plastic pollution by establishing a mandatory global cap on plastic production and limiting manufacture of single-use plastics.
    • Prattichizzo F, Ceriello A, Pellegrini V, La Grotta R, Graciotti L, Olivieri F, Paolisso P, D'Agostino B, Iovino P, Balestrieri ML, Rajagopalan S, Landrigan PJ, Marfella R, Paolisso G. Micro-nanoplastics and cardiovascular diseases: evidence and perspectives. Eur Heart J. 2024 Oct 7;45(38):4099- 4110. doi: 10.1093/eurheartj/ehae552.
  • In March 2024, we published an editorial in The New England Journal of Medicine, Plastics, Fossil Carbon and The Heart”. New Engl J Med 2024; 390:10. doi:10.1056/NEJMe2400683

Climate Change and Human Health

  • In April 2024, we published an editorial in Circulation, “Fossil Fuels, Climate Change and Cardiovascular Disease: A Call to Action.” Circulation, 2024; Apr 30;149(18):1400-1401. doi: 10.1161/circulationaha.123.065904

  • Landrigan PJ, Frumkin H, Lundberg B. The False Promise of Natural Gas. New England J Med,2019; 382: 104-107. doi: 10.1056/NEJMp1913663
    • This widely read editorial commentary argues that natural gas is neither a safe nor non- polluting fuel, as has been claimed, but that instead it is linked to disease, disability and premature death and is a major driver of climate change.
    • It concluded that investments in the natural gas infrastructure are at high risk of becoming stranded assets as the transition to renewable energy accelerates and the costs of clean energy continue to fall.

Pollution and Cardiovascular Disease

  • Rajagopalan S, Landrigan PJ. Pollution and the Heart. New England Journal of Medicine. 2021 Nov 11;385(20):1881-92. doi: 10.1056/NEJMra2030281
    • This report in the United States’ premier medical journal alerted doctors, nurses and public health workers to the reality that climate-driven air pollution is an important, often overlooked and preventable cause of heart disease and stroke.
  • Muenzel T, Kuntic M, Lelieveld J, Aschner M, Nieuwenhuijsen M, Landrigan PJ, Daiber A. The links between soil and water pollution and cardiovascular disease. Atherosclerosis,

  • Rajagopalan S, McAlister S, Jay J, Pham R, Brook R, Nasir K, Nieuwenhuijsen M, Landrigan P, Wiesler A, Sanborn C, Carron J, Brooks K, Bhatnagar A, Al-Kindi S. Towards environmental sustainability in cardiovascular practice: challenges and future directions Nature Reviews Cardiology, 25 October 2024

  • Landrigan PJ. Environmental risk factors go mainstream in pediatric cardiology. Professional Heart Daily. April 15, 2024.

  • Münzel T, Hahad O, Lelieveld J, Aschner M, Nieuwenhuijsen MJ, Landrigan PJ, Daiber A. Soil and water pollution and cardiovascular disease. Nat Rev Cardiol. 2024 Sep 25. doi: 10.1038/s41569- 024-01068-0.

COVID-19

  • Landrigan PJ, Ferrer L, Keenan J. COVID-19 and Health Disparities: Structural Evil Unmasked.Annals of Global Health. 2021; 87(1). doi.org/10.5334/aogh.3225
    • This report, jointly authored by a public health physician, a nurse-scientist, and one of Boston College’s leading Jesuit theologians, examined the ethical and moral bases for the stark elevations in disease and death from COVID-19 seen in poor, minority and marginalized populations